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A fictional affliction suffered by J. F. Sebastian in Ridley Scott's film Blade Runner. The syndrome is characterized by accelerated decrepitude in humans:
    Pris: How old are you?
    J.F.: (sighs) Twenty-five.
    Pris: What's your problem?
    J.F.: Methuselah syndrome.
    Pris: What's that?
    J.F.: My glands, they grow old too fast.

Methuselah syndrome is named after a biblical character mentioned in Genesis 5.21-27. The son of Enoch and the father of Lamech, Methuselah lived to the ripe old age of nine-hundred and sixty nine, making him the oldest person in the bible. He was also the great-great-great-great-great-grandson of Adam and the grandfather of Noah.

According to William Sanderson—the actor that portrayed J.F. Sebastian—part of his character was based on a film he saw of a child afflicted with progeria, a terrible disease that prematurely ages children.

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