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A family of receptors found in mammals that are thought to be involved in the recognition of pathogens by the immune system.

Named for their sequence homology to the Drosophila melanogaster receptor Toll.

As of January 2001, 10 Toll-like Receptors (TLRs) have been discovered.

Stimulation of Toll-like Receptors by bacterial components PAMPs lead to, among other things, TNF-alpha release and macrophage activation.

Here are what each receptor is thought to recognize (as of October 29, 2001):

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