A really big book, often with a thick, heavy-duty binding. Often used in fantasy stories to refer to magic spellbooks, and metaphorically for any book larger than others of its kind. (See The Wheel of Time.)

The largest tome I own is Merriam-Webster's New International Dictionary, Second Edition which is over 5 inches thick worth of 9-by-12 pages. This book also comes in an India paper edition which is thinner.