A NetHack item of very mixed usefulness and extreme power. This item is probably one of the most underrated in the game. Like all wands, you use it by zapping it at some target.

A wand of cancellation basically eliminates the magical or special powers of its target. Zapping a wand of cancellation at yourself cancels all of your items (see below) and removes any intrinsics, including luck modifiers. This is highly inadvisable unless you are desperate. It is also the number one reason not to zap yourself with random wands (what about the wand of death, I hear you asking? By the time you find one, you'll be past the zapping-self-with-random-wands phase). I did this once and walked away feeling depressingly mundane.

Zapping a wand of cancellation at an item removes that item's special powers. In particular:

Zapping this wand at a monster suppresses just about anything that makes that monster special. For example: If you put a wand of cancellation inside a bag of holding, the whole thing explodes, doing you a bunch of damage. The bag, the wand, and all items that were in the bag disappear for good. Yes, I did this once too. Don't ever put unidentified wands inside your bag of holding.