A biological technology developed by Monsanto to complement their Roundup weed-killer. Roundup (glyphosate) is a semi-biodegradable herbicide which works by inhibiting plant enolpyruvylshikimate-phosphate synthase (EPSPS). This enzyme is involved in aromatic amino acid (phenylalanine, tyrosine, and tryptophan) synthesis pathways and is thus crucial for normal protein synthesis in cells.

Roundup Ready plants have been genetically engineered to contain a bacterial EPSPS gene as well as their original one. The bacterial enzyme is not inhibited by glyphosate. As a result, the engineered plants are resistant to Roundup.

As with many GMO's and related technologies, Roundup Ready has been the subject of much heated debate between Monsanto, scientists, and anti-GMO groups such as Greenpeace. Some of the issues include economic exploitation of farmers, the human health effects of Roundup, and the danger of the gene "escaping" to wild relatives of crop plants.