Another update 20030929: Using this URL instead is less taxing on E2's servers because it searches for nodes via Google instead:

http://google.com/search?q=%s+-Findings:@+site:everything2.com
Update: stewacide says this is easier done using Tweak UI if you use Windows XP.
If you use IE on Windows, try saving the following contents between the tags into a .reg file in the usual ASCII encoding for Windows 95/98 or in Unicode encoding for Windows 2000:

< start e2.reg >
REGEDIT4

[HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\SearchUrl\e2]
@="http://www.everything2.com/index.pl?node=%s"
" "="+"
"#"="%23"
< end e2.reg >

Once you install this registry information by double-clicking the .reg file, try typing this into the address bar (without the parenthesis) and hit ENTER:
e2 (your search query here)
/msg me if you have trouble getting it to work.

Other ways to conveniently search Everything: