Health is extremely important in The Binding of Isaac, and not only because once it runs out you go back to the beginning in true roguelike fashion. Learning how to manage and use health to your advantage is a skill in TBoI much like dodging, and recognizing patterns. The aspiring player should learn these cases little by little in order to improve themselves over time.
Also, the aspiring game designer should, in my humble opinion, look up to this game to learn a trick or two on how to use health (or other resources) in their game. The complexity of this system is only a small part of why, almost a decade after its release, the game still sees love from both the developer and its players.
7: Health management or why having 1 HP is near-optimal
← Health in The Binding of Isaac