Effects of Mullerian Inhibiting Hormone (MIH)
Responsible in human
foetal development for preventing the
expression of
female physiology.
In conjunction with
androgens, cause the formation of the
male system
A
genetic disorder exists, known as
androgen insensitivity syndrome, which causes the malformation of androgen
receptors in the foetus and as a result, no
masculinization occurs; i.e. the
genotype of the individual is
XY, where as female physical and sexual characteristics (i.e. formation of breasts, womb and vagina) are
phenotypically expressed (as female is the 'default' setting), but not fully developed (due to activity of MIH) and the individual is rendered
infertile. A celebrity example of this condition is actress
Jamie Lee Curtis - phenotypically female, genotypically male.