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Founded by Samuel Arthur Brain and his uncle Joseph Benjamin Brain in 1882, at the site of the Old Brewery on St. Marys Street in Cardiff, Brains is the largest brewer in Wales.

Brains make a variety of beers including:

Brains SA
Brains Dark
Brains Bitter
Buckleys Best Bitter
Buckleys IPA
Buckeys Dark Ale
The Reverend James Ale
Dylans Smooth Ale
Arms' Park Ale

Brains also make St. Davids Ale (known as Cwrw Dewi Sant in Welsh) every spring, around about St. Davids Day

The company no longer use the Old Brewery, but during the 1999 Rugby World Cup, the yard was converted into a giant pub, with a 100 foot bar, and 2 huge screens to watch the games on.

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