A hesitation noise in the Japanese language. An alternative for Japanese speakers would be "etoo..."
I would approximate it to the English "Uhh..." or "Umm...".

The "noo" is not pronounced as in the English "noose", but is instead an example of long vowels in Japanese. Were it to use a short vowel sound instead, it would be written "ano".

Anoo can be alternatively written in romaji as anou.