Colossus is the master of cartoon supervillainy featured in The Simpsons episode Who Shot Mr. Burns? (Part II). He is a spoof of the James Bond and Batman villains (and don't forget Dr. Evil from Austin Powers). His greatest weapon is his amazing Colosso-boots that allows him to get taller, with the disadvantage of hitting the ceiling.

Quote (refering to the death of Mr. Burns):
Bah! He was a rank amateur compared to Doctor Colossus! Oh-hah-hah-hah

Note: some informations were taken from the book The Simpsons, A Complete Guide To Our Favorite Family, (c) 1997 Matt Groening Productions, Inc.