Delestrogen® Injection

Brand Names: Alora®; Climara®; Delestrogen®; DepGynogen®; Depo-Estradiol®; Depogen®; E-Cypionate®; Esclim®; Estrace®; Estrace® VR; Estraderm®; Estragyn LA 5®; Estrasorb™; Estring®; Estro-Cyp®; Estro-L.A.®; FemPatch®; Gynodiol®; Gynogen LA®; Innofem®; Menaval®; Noven®; Vagifem™; Valergen®; Vivelle™; Vivelle-Dot™  This medication is manufactured by Bristol-Myers Squibb Company.

Estradiol Valerate® Injections, (Delestrogen® Injections) are injections containing an estrogen female hormone. Estrogens are essential for maintaining normal female functions. Estrogens can help relieve symptoms of  menopause such as: hot flashes, night sweats, mood changes, and vaginal dryness and irritation. Estrogens can also help improve female functions in women with hormonal imbalance or problems with their ovaries. Estrogens can be given to patients with inoperable breast cancers (in men or women) or prostate cancer. Generic estradiol cypionate and estradiol valerate injections are available.

Your health care professional should know if you have any of the following complications:

Drugs that may interact with Delestrogen® Injections:

  • some antibiotics used to treat infections
  • some medications used to treat HIV (human immunodeficiency virus) infection or AIDS
  • ascorbic acid/vitamin C supplements
  • barbiturates or benzodiazepines used for inducing sleep or treating seizures (convulsions)
  • bromocriptine
  • carbamazepine
  • cimetidine
  • clofibrate
  • cyclosporine
  • dantrolene
  • medications for diabetes
  • griseofulvin
  • hormones
  • hydrocortisone, cortisone, or prednisolone
  • imipramine or some other antidepressants
  • isoniazid (INH)
  • methotrexate
  • mineral oil
  • phenytoin
  • raloxifene or tamoxifen rifabutin, rifampin, or rifapentine
  • some medications for treating migraines
  • theophylline
  • thyroid hormones
  • topiramate
  • tricyclic antidepressants
  • warfarin

Medication Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F); do not freeze. Throw away any unused medicine after the expiration date.

Keep out of the reach of children.


In addition to the risks listed above, the following side effects have been reported with estrogen use:  nausea and vomiting, breast tenderness or enlargement, enlargement of benign tumors ("fibroids") of the uterus, retention of excess fluid.  This may make some conditions worsen, such as asthma, epilepsy, migraine, heart disease, or kidney disease, or a spotty darkening of the skin, particularly on the face

Personal Experience:

I was suffering from hot flashes, night sweats, sleeping problems and mood swings before taking this medication.  I have to go the the physician's office once a month to have the injection administered into my hip.  It has been a life saver for me after my hysterectomy at the age of 30.  All of the problems I had before are almost non-existent now.

Source: Ebscohost Research Database. 23 Jul 2004;.

Monarch Pharmaceuticals. Patient information for Delestrogen. Bristol: , 2002.

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