According to Wikipedia:
Ho is a town in southeast Ghana and is the capital of the Volta Region.

With that out of the way, another definition that sees more use in the American vernacular. From wiktionary:

A whore; a sexually loose woman; in general use as a highly offensive name-calling word for a female with connotations of loose sexuality.

Finally, I'd like to draw your attention to the apparent prescience of Webster 1913, where the first line for this word reads:

Ho (?), pron.

which presages both a modern alternative spelling of "pornography" and the association of prostitution with this industry sector.

Ho (?), pron.

Who. [Obs.] In some Chaucer MSS.


© Webster 1913.

Ho, Hoa (?), n. [See Ho, interj., 2.]

A stop; a halt; a moderation of pace.

There is no ho with them. Decker.


© Webster 1913.

Ho, Hoa (?), interj. [Cf. F. & G. ho.]


Halloo! attend! -- a call to excite attention, or to give notice of approach.

"What noise there, ho?"


"Ho! who's within?" Shak.

2. [Perhaps corrupted fr. hold; but cf. F. hau stop! and E. whoa.]

Stop! stand still! hold! -- a word now used by teamsters, but formerly to order the cessation of anything.

[Written also whoa, and, formerly, hoo.]

The duke . . . pulled out his sword and cried "Hoo!" Chaucer.

An herald on a scaffold made an hoo. Chaucer.


© Webster 1913.

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