There is a theory behind the gender change of Data's cat "Spot".

Early in the series, Spot was referred to as a "he", however Spot later gave birth to kittens in the de-evolution episode. (Genesis - Ep. #71)

The theory claims he was the unfortunate victim of a transporter malfunction, turning him into a "she."

In this event, the transporter (quite literally) ate Spot's balls.

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