conjugated estrogens (thing)

Pharmacologic class

Hormone

Premarin

Hormone replacement therapy - (see brand name writeup for details)

Conjugated estrogens derived from animal sources have the same effect as natural endogenous hormones in the body, stimulating estrogen receptor-containing cells, particularly in the female reproductive system, breasts, and secondary gender specific characteristics.

Pregnancy (Category X), breast cancer, clotting disorders, undiagnosed vaginal bleeding

A progesterone should be used with estrogens unless the uterus has been removed. Caution should be used if the patient has liver or gallbladder disease, also with some diseases of the bone associated with high calcium. Not recommended for teenagers and nursing mothers.

No common interactions known

Increased risk of estrogen-dependent cancers, gallstones, blood clots, liver tumors, nausea, uterine bleeding, edema, weight gain, sore breasts, high blood pressure, depression, and intolerance to contact lenses.

Patients taking estrogens should have both an initial complete physical and repeat annual physicals including blood pressure, mammograms, and a PAP smear. Stop the medicine if jaundice or high blood pressure occurs or if immobilized or for at least two weeks before any surgery associated with thromboembolism.

Current studies released in July of 2002 recommend not taking estrogen / progesterone combinations for prevention of heart disease and stroke, or to lower cholesterol levels. The relative risk of morbidity and mortality is actually increased in patients taking these medications rather than descreased. Taking estrogens for relief of symptoms of menopause or for other reasons listed above is still a reasonable course of action, and should be discussed with your doctor.

August 5, 2002