Three kinds of lice affect humans; infestation with lice is known as pediculosis. The louse itself is a small wingless flattened insect.

Pediculosis capitis, head louse infestation, affects the scalp, although sometimes it involves the eyebrows, eyelashes, and beard; it is particularly common in children. The lice feed on blood from the scalp, having infested it by direct contact with hair and with items such as combs, towels, and headgear. The bites cause severe persistent itching and the lesions may become infected. The glands of the neck may sometimes enlarge.

Adult lice may be noticed around the back of the head and behind the ears. The small ovoid eggs, or nits, are easier to detect, being firmly attached to hair shafts. These hatch in three to fourteen days unless removed with a nit comb. In addition to combing, the scalp should be treated with benzyl benzoate or gamma benzene hexachloride (GBH). Members of the same household also should be examined for infestation.

Pediculosis corporis, body louse infestation, occurs when lice inhabit the seams of clothing worn next to the skin and feed on the skin. Under good hygienic conditions it is uncommon. The bites of the lice appear as small red marks, and itching may lead to severe scratch marks with secondary bacterial infection. Lesions are especially common on the shoulders, buttocks, and abdomen. Both the parasites and nits show up readily in clothing.

Laundering and hot ironing of seams will kill the lice. The skin should be rubbed with GBH. Lotions may soothe inflammation. Nits remain viable in clothing for as long as one month, hatching when they are reexposed to body heat. Dissemination of lice occurs through contact with infected persons, clothing, or bedding.

Pediculosis pubis is crab louse infestation of the area of the genitals and anus and sometimes other hair regions. Infestation may be venereal or acquired from clothing, bedclothes or toilet seats. Severe irritation, with scratch marks, occurs. Application of benzyl benzoate or GBH is an effective treatment. Prolonged use of such chemicals should be avoided, however.

Lice are known to transmits typhus fever, relapsing fever, and trench fever, but these infections are rare.