The first
organism that has been
considered for
intentional extinction. It is
believed that
smallpox has been totally
eradicated in the
world, as there have been no
reported cases in a long time.
There are currently a some cultures in a few labs scattered around the world. There has been some discussion about whether those cultures should be destroyed, making it possible that smallpox could be forever gone from this planet. However, there are always worries that it may not be gone from nature, and eliminating those cultures could make creating vaccines take a bit longer. There's also the possibility that research on smallpox may have scientific value.
Nobody seems to be in a hurry to destroy those cultures, so there's a good chance it'll stay around for a while longer.