A series of American Idiom derived from baseball. Used primarily by teen and pre-teen boys to indicate what they have done with their female date. The following is the standard list although there are variations.

first base: kissing

second base: touching the girl's breasts (some would define this as kissing with tongues instead)

third base: touching the girl's genitals or putting hand under panties (some in this hedonistic age would define this as oral sex)

home run / fourth base: having sex.