To obliterate, to frag, to gib, to sputch. From "supreme", e.g. "He got supremely fucked up," evolved to "He got spreemed." Most appropriate to FPS games or the use of firearms, when all that's left of the spreemee are little bits. Applicable to any large amount of destruction that takes place over a short period of time, i.e., massive downvoting.
"Writing a GTKY node is like running from the LAPD into a crack house; not only do you get spreemed, but everyone else who posted there gets a piece!"