In Asimov's original Galactic Empire and Foundation novels, Trantor was located at the exact center of the Galaxy. This example of central place theory1 taken to extremes was an important part of the mythical image Asimov was trying to construct, and figured prominently in the plot2.

The impossibility of Trantor being in this location was eventually pointed out to Asimov, who, when he began the commerical milking of his series with Foundation's Edge, moved Trantor to the galactic disk, just ouside the Core.

This seems like a shame to me.

1Who said Isaac Asimov wasn't a geographer?
2I'm tying to be careful here, OK?