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Starting with a potion of polymorph is something really great. Throw this potion to your pet and it is likely to change to a more useful form than a kitten/little dog. Last time this situation happened, my pet changed to a blue dragon which killed everything in sight, even shopkeepers.

If you don't know the potion of polymorph at the start of the game (which is the case 99.5% of the time), I would recommend you to take off your cloak and armor before you drink a costly potion because if you ever hit this potion, you might break your armor and cloak permanently...