In the above-mentioned "The Onion" interview with Craig MacKracken (the creator of the show), apart from saying that the show was originally called "The Kick-Ass Girls" he also noted that it was mainly aimed at college kids doing drugs in their dorms and watching the show.

So true.

The show's humor can be compared to The Simpsons, as a large number of jokes in it will not be understood by kids. Oh so good.