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Story editor J. Michael Straczynski went on to fame as the creator and executive producer of Babylon 5. The aforementioned hour-long expansion of the show into "Slimer! and the Real Ghostbusters" coincided with his separation from the show; the inclusion of "Junior Ghostbusters", the removal of all personality from Janine (turning her into a mommy figure), and the bad animation of the Slimer! segment marked the death of the cartoon.

The character likenesses were changed so the producers wouldn't have to pay royalties to Bill Murray and company. This led to an amusing episode in which a film studio sought the rights to film the story of their first adventure...

                 RAY
            (reading contract)
        Murray, Aykroyd, and Ramis?

                 PETER
        Sounds like a law firm.